Soluble mesothelin-related peptides (SMRP) are breakdown products from proteins found in the membranes that line the cavities surrounding the lungs, heart, and abdomen. High amounts of SMRP are often seen in the blood of people suffering from mesothelioma, and the amount of SMRP in the blood is thought to be related to the extent of disease. This test measures the amount of SMRP in the blood.